It is freely soluble in methanol slightly soluble in ethanol, chloroform, and isopropanol and sparingly soluble in water.ĪDVAIR DISKUS is a purple plastic inhaler containing a foil blister strip. Salmeterol xinafoate is a white powder with a molecular weight of 603.8, and the empirical formula is C 25H 37NO 4 It has the chemical name 4-hydroxy-α 1-amino]methyl]-1,3-benzenedimethanol, 1-hydroxy-2naphthalenecarboxylate and the following chemical structure: Salmeterol xinafoate is the racemic form of the 1-hydroxy-2-naphthoic acid salt of salmeterol. The other active component of ADVAIR DISKUS is salmeterol xinafoate, a beta 2-adrenergic bronchodilator. It is practically insoluble in water, freely soluble in dimethyl sulfoxide and dimethylformamide, and slightly soluble in methanol and 95% ethanol. One active component of ADVAIR DISKUS is fluticasone propionate, a corticosteroid having the chemical name S-(fluoromethyl) 6α,9-difluoro-11β,17-dihydroxy-16α-methyl-3oxoandrosta-1,4-diene-17β-carbothioate, 17-propionate and the following chemical structure:įluticasone propionate is a white powder with a molecular weight of 500.6, and the empirical formula is C 25H 31F 3O 5S. DESCRIPTIONĪDVAIR DISKUS 100/50, ADVAIR DISKUS 250/50, and ADVAIR DISKUS 500/50 are combinations of fluticasone propionate and salmeterol xinafoate. Do not use ADVAIR DISKUS for patients whose asthma is adequately controlled on low-or medium-dose inhaled corticosteroids. Once asthma control is achieved and maintained, assess the patient at regular intervals and step down therapy (e.g., discontinue ADVAIR DISKUS) if possible without loss of asthma control and maintain the patient on a long-term asthma control medication, such as an inhaled corticosteroid. Therefore, when treating patients with asthma, physicians should only prescribe ADVAIR DISKUS for patients not adequately controlled on a long-term asthma control medication, such as an inhaled corticosteroid, or whose disease severity clearly warrants initiation of treatment with both an inhaled corticosteroid and a LABA. Available data from controlled clinical trials suggest that LABA increase the risk of asthma-related hospitalization in pediatric and adolescent patients. Currently available data are inadequate to determine whether concurrent use of inhaled corticosteroids or other long-term asthma control drugs mitigates the increased risk of asthma-related death from LABA.
#Advair discus side effects trial#
trial that compared the safety of salmeterol with placebo added to usual asthma therapy showed an increase in asthma-related deaths in subjects receiving salmeterol (13 deaths out of 13,176 subjects treated for 28 weeks on salmeterol versus 3 deaths out of 13,179 subjects on placebo). Data from a large placebo-controlled U.S. Long-acting beta 2-adrenergic agonists (LABA), such as salmeterol, one of the active ingredients in ADVAIR DISKUS®, increase the risk of asthma-related death. You may report side effects to FDA at 1-80. For more information, ask your doctor or pharmacist.Ĭall your doctor for medical advice about side effects. These are not all the possible side effects of Advair Diskus. Tell the doctor if you have any side effect that bothers you or that does not go away. cold symptoms ( stuffy nose, sneezing, sore throat).The most common side effects of Advair Diskus include: Get medical help right away, if you have any of the symptoms listed above. sores or white patches in your mouth or throat,.breathing problems after using the medication,.What are the possible side effects of Advair Diskus?Īdvair Diskus may cause serious side effects including:
It is not known if Advair Diskus is safe and effective in children younger than 4 years of age. Advair Diskus may be used alone or with other medications.Īdvair Diskus belongs to a class of drugs called Respiratory Inhalant Combos COPD Agents. Find Lowest Prices on What is Advair Diskus and how is it used?Īdvair Diskus is a prescription medicine used to treat the symptoms of Asthma and Chronic Obstructive Pulmonary Disease.
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